After carefully choosing a target indication, the process
of selecting a native protein to evolve through mutation and develop into a
novel therapeutic begins. SmartZyme first conducts a comprehensive review of
the available scientific literature and IP estates. This is followed by a computational
analysis of the native protein’s structure, which serves to focus the
experimental process. Once in the lab, SmartZyme utilizes its powerful directed
evolution approach to randomly manipulate the gene which translates the protein.
The result is a library with billions of different protein variants, all of
which are then screened to determine the best performers. Click “Read More” to
find out what makes our process special.