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Monitoring of Immunoglobulin N- and O-glycosylation in Health and Disease.

Monitoring of Immunoglobulin N- and O-glycosylation in Health and Disease.

Protein N- and O- glycosylation are well-known co- and post-translational modifications of immunoglobulins. Antibody glycosylation on the Fab and Fc portion is understood to affect antigen binding and effector features, respectively. To check associations between antibody glycosylation profiles and (patho)physiological states in addition to antibody performance, superior applied sciences and strategies are required. In-depth structural characterization of antibody glycosylation often depends on the separation and tandem MS evaluation of launched glycans. Protein- and site-specific data, alternatively, could also be obtained by the MS evaluation of glycopeptides.

With the event of high-resolution mass spectrometers, antibody glycosylation evaluation on the intact or middle-up stage has gained extra curiosity, offering an built-in view of various post-translational modifications (together with glycosylation). Alongside the in-depth strategies, there’s additionally nice curiosity in sturdy, high-throughput methods for routine glycosylation profiling in biopharma and scientific laboratories. With an emphasis on IgG Fc glycosylation, a number of extremely sturdy separation-based methods are employed for this goal. On this overview, we describe current advances in mass spectrometric strategies, separation methods and orthogonal approaches for the characterization of immunoglobulin glycosylation in numerous settings. We put emphasis on the present standing and anticipated developments of antibody glycosylation evaluation in biomedical, biopharmaceutical and scientific analysis.

Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody-Drug Conjugates to Polydisperse Membrane Proteins and Past.

Electrospray ionization mass spectrometry (ESI-MS) is a ubiquitously used analytical technique utilized throughout a number of departments in biopharma, starting from early analysis discovery to course of growth. Correct, environment friendly, and constant protein MS spectral deconvolution throughout a number of instrument and detector platforms (time-of-flight, Orbitrap, Fourier-transform ion cyclotron resonance) is crucial.

When proteins are ionized in the course of the ESI course of, a distribution of consecutive multiply charged ions are noticed on the m/z scale, both constructive [M + nH]n+ or detrimental [M – nH]n relying on the ionization polarity. The guide calculation of the impartial molecular weight (MW) of single proteins measured by ESI-MS is easy; nevertheless, algorithmic deconvolution is required for extra complicated protein mixtures to derive correct MWs. A number of deconvolution algorithms have developed over the previous twenty years, all of which have their benefits and downsides, when it comes to pace, user-input parameters (or ideally lack thereof), and whether or not they carry out optimally on proteins analyzed underneath denatured or native-MS and resolution situations.

 

Herein, we describe the utility of a parsimonious deconvolution algorithm (explaining the noticed spectra with a minimal variety of plenty) to course of a variety of extremely numerous biopharma related and analysis grade proteins and complexes (PEG-GCSF; an IgG1ok; IgG1- and IgG2-biotin covalent conjugates; the membrane protein complicated AqpZ; a extremely polydisperse empty MSP1D1 nanodisc and the tetradecameric chaperone protein complicated GroEL) analyzed underneath native-MS, denaturing LC-MS, and constructive and detrimental modes of ionization, utilizing a number of devices and subsequently a number of information codecs. The implementation of a comb filter and peak sharpening possibility can be demonstrated to be extremely efficient for deconvolution of extremely polydisperse and enhanced separation of a low stage lysine glycation post-translational modification (+162.1 Da), partially processed heavy chain lysine residues (+128.1 Da), and lack of N-acetylglucosamine (GlcNAc; -203.1 Da).

Monitoring of Immunoglobulin N- and O-glycosylation in Health and Disease.

Nanoscale integration of single cell biologics discovery processes utilizing optofluidic manipulation and monitoring.

The brand new and speedy development within the complexity of biologics drug discovery has been pushed by a deeper understanding of organic techniques mixed with progressive new therapeutic modalities, paving the best way to breakthrough therapies for beforehand intractable illnesses. These thrilling occasions in biomedical innovation require the event of novel applied sciences to facilitate the subtle, multifaceted, high-paced workflows essential to help trendy giant molecule drug discovery.
A high-level aspiration is a real integration of “lab-on-a-chip” strategies that vastly miniaturize cellulmical experiments might rework the pace, price, and success of a number of workstreams in biologics growth. A number of microscale bioprocess applied sciences have been established that incrementally handle these wants, but every is inflexibly designed for a really particular course of thus limiting an built-in holistic software. A extra totally built-in nanoscale strategy that comes with manipulation, tradition, analytics, and traceable digital report maintaining of hundreds of single cells in a related nanoenvironment can be a transformative know-how able to maintaining tempo with in the present day’s speedy and sophisticated drug discovery calls for.

Uterus Membrane Lysate

XBL-11023 0.1 mg
EUR 516.5
Description: Human uterus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human uterus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated uterus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated uterus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Rabbit SCLERA YG FROZEN 1 EA

41216-1 1 Each
EUR 83.49

Rabbit HEART YG FROZEN 50 EA

41218-2 50 Each
EUR 342.31

Rabbit MUSCLE TISSUE MT FROZEN 1kg

41325-2 1 kg
EUR 281.41

Bovine UTERUS 5 EA*

57153-2 5 EA
EUR 204.2

Human Uterus Tumor lysate

HTL-1384 1 mg
EUR 773

Uterus Tissue Slide (Normal)

11-401-10um 10 um
EUR 201.5

Uterus Tissue Slide (Normal)

11-401-4um 4 um
EUR 180.5

Uterus Tissue Slide (Benign)

11-402-10um 10 um
EUR 201.5

Uterus Tissue Slide (Benign)

11-402-4um 4 um
EUR 180.5

Uterus Tissue Slide (Adenocarcinoma)

11-404-10um 10 um
EUR 201.5

Uterus Tissue Slide (Adenocarcinoma)

11-404-4um 4 um
EUR 180.5

Uterus Tissue Slide (Abnormal)

11-419-10um 10 um
EUR 201.5

Uterus Tissue Slide (Abnormal)

11-419-4um 4 um
EUR 180.5

Uterus Tissue Slide (Adenomyoma)

11-432-10um 10 um
EUR 201.5

Uterus Tissue Slide (Adenomyoma)

11-432-4um 4 um
EUR 180.5

Uterus Membrane Tumor Lysate

XBL-11031 0.1 mg
EUR 626.75
Description: Human uterus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human uterus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated uterus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated uterus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Uterus-Corpus Membrane Lysate

XBL-11037 0.1 mg
EUR 516.5
Description: Human uterus-corpus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human uterus-corpus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated uterus-corpus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated uterus-corpus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Uterus-Fundus Membrane Lysate

XBL-11040 0.1 mg
EUR 516.5
Description: Human uterus-fundus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human uterus-fundus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated uterus-fundus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated uterus-fundus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Control Sections for FD NeuroSilver™ Kit

PCS101 each
EUR 58

Fine natural hair brush for mounting sections

PO501 each
EUR 67

CancerSeq? Plus Paraffin Tissue Tumor Sections: Breast

T2235086-SC 5 curls
EUR 932
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

CancerSeq? Plus Paraffin Tissue Tumor Sections: Stomach

T2235248-SC 5 curls
EUR 932
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

CancerSeq? Plus Paraffin Tissue Tumor Sections: Thyroid

T2235265-SC 5 curls
EUR 932
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Total RNA from Human Adult Normal Tissue: Uterus: Cervix of uterus

R1234275-50 50 ug
EUR 178
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Uterus: Corpus of Uterus

R1234276-10 10 ug
EUR 194
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rabbit PSOAS MUSCLE YG FROZEN 1 EA

41217-1 1 Each
EUR 180.28

Total RNA from Lupus: Uterus

R1236274Lup-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Uterus Tissue Slide (Endometrioid Adenocarcinoma)

11-405-10um 10 um
EUR 201.5

Uterus Tissue Slide (Endometrioid Adenocarcinoma)

11-405-4um 4 um
EUR 180.5

Control sections for FD NeuroApop™ Kit (paraffin)

PCS102-1 each
EUR 67.03
Description: Best quality products

FD NeuroSilver™ Kit II (for 300 sections)

PK301 kit
EUR 792

FD NeuroSilver™ Kit II (for 150 sections)

PK301A kit
EUR 658

Total RNA from Human Adult Normal Tissue 5 Donor Pool: Uterus: Cervix of uterus

R1234275-P 50 ug
EUR 328
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Tumor Tissue: Uterus

C1235274 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Uterus Tissue Slide ( Papillary serous Adenocarcinoma)

11-407-10um 10 um
EUR 201.5

Uterus Tissue Slide ( Papillary serous Adenocarcinoma)

11-407-4um 4 um
EUR 180.5

Uterus Tissue Slide (Spindle Cell Tumor)

11-418-10um 10 um
EUR 201.5

Uterus Tissue Slide (Spindle Cell Tumor)

11-418-4um 4 um
EUR 180.5

Monkey (Rhesus) Normal Uterus Whole tissue lysate

MRL-1332 1 mg
EUR 773

Monkey (Cyno.) Normal Uterus Whole tissue lysate

MCL-1222 1 mg
EUR 773

Human Adult Uterus (Normal) Whole tissue lysate

HAL-1317 1 mg
EUR 524

cDNA from Human Adult Normal Tissue: Uterus

C1234274 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Uterus

C1534274 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Uterus

C1534274-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

FFPE Genomic DNA - Human Tumor Tissue: Uterus

D2235274 2 ug
EUR 821
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Tumor Tissue: Uterus

P1235274 1 mg
EUR 320
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Tumor Tissue: Uterus

P3235274 0.1 mg
EUR 408
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Tumor Tissue: Uterus

R1235274-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Paraffin Tissue Section - Human Adult Normal: Uterus

T2234274 5 slides
EUR 211
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Paraffin Tissue Section - Human Uterus Cervix Tumor

T2235275 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Adrenal

T1236004Lup 5 slides
EUR 474
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Arteriosclerosis: Aorta

T1236012Hd-4 5 slides
EUR 976
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Artery

T1236013Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Arteriosclerosis: Artery

T1236013Hd-4 5 slides
EUR 976
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Vein

T1236020Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Heart

T1236122Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Kidney

T1236142Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Kidney

T1236142Lup 5 slides
EUR 534
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Asthma: Lung

T1236152Ld-1 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Bronchitis: Lung

T1236152Ld-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Emphysema: Lung

T1236152Ld-3 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Pneumonia: Lung

T1236152Ld-4 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Ovary

T1236183Lup 5 slides
EUR 611
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Pancreas

T1236188Lup 5 slides
EUR 474
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Spleen

T1236246Lup 5 slides
EUR 474
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I

T6834700-G01-1 1 slide
EUR 258
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I

T6834700-G01-5 5 slides
EUR 821
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I

T6834700-G02-1 1 slide
EUR 258
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I

T6834700-G02-5 5 slides
EUR 821
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Human Uterus Tissue Slide (Normal) (5 slides/pk)

HTS-11401 1 pk
EUR 286

Human Uterus Tissue Slide (Benign) (5 slides/pk)

HTS-11402 1 pk
EUR 286

Human Uterus Tissue Slide (Adenocarcinoma) (5 slides/pk)

HTS-11404 1 pk
EUR 286

Human Uterus Tissue Slide (Abnormal) (5 slides/pk)

HTS-11419 1 pk
EUR 286

Human Uterus Tissue Slide (Adenomyoma) (5 slides/pk)

HTS-11432 1 pk
EUR 286

cDNA from Human Adult Normal Tissue: Uterus: Cervix

C1234275 40 reactions
EUR 376
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus: Corpus

C1234276-10 10 reactions
EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus: Fundus

C1234278-10 10 reactions
EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Uterus: Cervix

C1534275 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Uterus: Cervix

C1534275-Cy 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Uterus: Corpus

C1534276 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Uterus: Fundus

C1534278 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Adult Normal Tissue: Uterus

P1234274 1 mg
EUR 214
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Uterus

P3234274 0.1 mg
EUR 285
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Adult Normal Tissue: Uterus

R1234274-50 50 ug
EUR 178
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Paraffin Tissue Section - Human Uterus Tumor: Endometrium Adenocarcinoma

T2235274-3 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Matching Pair - Paraffin Tissue Sections - Human Primary Tumor and Normal (PP): Stomach

T8235248-PP 5 slides x2
EUR 403
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Zenoquick Frozen-EZ Yeast Transformation Kit

Z6002-001 1Kit
EUR 226

Frozen Tissue Section - Human Tumor: Adrenal

T1235004 5 slides
EUR 338
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Tumor: Bladder

T1235010 5 slides
EUR 338
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Tumor: Bone

T1235023 5 slides
EUR 338
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Tumor: Brain

T1235035 5 slides
EUR 338
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
The current introduction of optical manipulation of cells utilizing light-induced electrokinetics with micro- and nanoscale cell tradition is poised to revolutionize each elementary and utilized organic analysis. On this overview, we summarize the present cutting-edge for optical manipulation methods and talk about rising organic functions of this know-how. Particularly, we give attention to promising prospects for drug discovery workflows, together with antibody discovery, bioassay growth, antibody engineering, and cell line growth, that are enabled by the automation and industrialization of an built-in optoelectronic single-cell manipulation and tradition platform. Continued growth of such platforms will likely be properly positioned to beat most of the challenges at the moment related to fragmented, low-throughput bioprocess workflows in biopharma and life science analysis.

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